Assist Your Recovery And Induce Restfulness With The All New Chemix Ultra Premium Sleep Aid. The Guerrilla Chemist Has Gone Back To The Lab And Formulated Our First Ever Ultra Premium Sleep Aid Product. This One Of A Kind Formulation Will Turn Your Lights Out When It's Time To Get Your Rest. Chemix Sleep Will Provide The Best In Rest And Recovery With No Excess Hangover Leaving You Ready To Take On The Day With Plenty Of Energy And Focus.

SLEEP is an all-natural, multifaceted sleep product designed to promote sleepiness and restful sleep to ensure maximum recovery. Quality sleep is one of the most important and essential actions your body needs to function properly. It is estimated that up to 33% of all adults do not get enough quality sleep. SLEEP is specifically designed to help fight off restlessness via different mechanisms of action, including inducing sleep and staying asleep.

HOW DOES CHEMIX SLEEP WORK?

GABAiclinÔ is a trademarked extract of Scutellaria baicalensis, standardized for 30% of the main active baicalin. Baicalin is a positive allosteric agonist for your GABA_A receptors. g-aminobutyric acid, aka GABA is your main inhibitory neurotransmitter that essentially tells your brain it’s time to get ready for sleep. Once baicalin binds to your GABA_A receptor, it activates the receptor and elicits sedative, hypnotic, muscle relaxant and anxiolytic(anti-anxiety) properties.  This is the same mechanism and receptor that a class of sleep medications known as benzodiazepines interacts with. Baicalin has been shown to increase slow-wave sleep(deep sleep), as well as REM(rapid eye movement) sleep. REM sleep is extremely valuable to your body, as it releases growth hormone(GH) to help aid in recovery.

MagnaSleepÔ is an extremely potent form of magnolia bark extract(MBE), standardized for 90% of two powerful active phenolic compounds: magnolol and honokiol.  These two bioactives also act on your GABA_A receptors to help reduce anxiety and prepare your body for sleep. MBE has been used for thousands of years in Chinese and Japanese tradition medicine for help promote sleep and reduce anxiety. Magnolol and Honokiol both have very high binding affinity to your GABA_A receptors, specifically interacting with the benzodiazepine binding site. This binding potentiates the sleep inducing-effect of baicalin. Since magnolol and honokiol can quickly be metabolized via glucuronidation, a hefty 25mg dose of BioPerineÒ(black pepper extract) was added to inhibit this process.

Cussonia zimmermannii is an African herb that has been studied for bioactive constituents that modulate your GABA receptors to induce sleep. The rootbark extract of C. zimmermannii has some very unique compounds known as polyacetylenes that have an extremely high affinity to GABA_A receptors. However instead of binding directly to the receptor binding pocket, they bind to a slightly different area on the GABA_A receptors and enhance the effects of compounds like magnolol and honokiol that bind directly to the binding pocket. This is known as positive allosteric modulation and is a very synergistic property.   These compounds have been shown to promote restfulness sleep, as well as staying asleep longer.

Hesperidin is one of the main bioactive compounds from citrus peel extract. It is a polyphenolic compound that has been shown to induce sleep, but does not act on the GABA receptor or benzodiazepine binding site.  Studies show hesperidin interacts with your extracellular signal-regulated kinases 1/2(ERK1/2), located in the cortex and cerebellum. Hesperidin inhibits the activity of ERK1/2, which may be linked to sedation. Studies show that hesperidin can induce sleepiness and enhance sleep, and may potentiate other sleep-promoting compounds that activate your GABA_A receptors.

Apigenin is a polyphenolic flavonoid that is one of the most abundant and well-studied. Apigenin’s mechanism of action is not directly on the GABA-benzodiazepine receptor, but does modulate its’ activity. Studies show it has a synergistic effect when combined with GABA_A agonists, like baicalin, magnolol and honokiol.  It has been shown to reduce locomotor activity, which prevents restlessness and may help induce sleep. One study showed subjects taking apigenin slept for longer durations vs the placebo. Apigenin is also subject to glucuronidation, so absorption is critical.  With 25mg of BioPerineÒ added to prevent this metabolism, you can be sure that the large dose of apigenin will be absorbed and utilized.

I formulated SLEEP because I have had sleeping issues all of my adult life. I have tried countless over-the-counter sleeping aids, melatonin, as well as 11 different pharmaceuticals.  This combination of ingredients at clinical doses has dramatically improved my ability to fall asleep, my biggest issue, as well as stay asleep, my 2^nd biggest issue.  I scoured papers to look for natural sleep-enhancing compounds and I truly believe this formula will help anyone looking to get more restful sleep to help fully recover not only from exercise but from mental stress, as well.

-GC

References:

1. Chang HH, Yi PL, Cheng CH, et al. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. J Ethnopharmacol. 2011;135(2):359-368.
2. Shi, Yuan, et al. "Herbal insomnia medications that target GABAergic systems: a review of the psychopharmacological evidence." Current Neuropharmacology3 (2014): 289-302.
3. Ai, Jinglu, Xiaomei Wang, and Mogens Nielsen. "Honokiol and magnolol selectively interact with GABAA receptor subtypes in vitro." Pharmacology1 (2001): 34-41.
4. Squires, Richard F., et al. "Honokiol and magnolol increase the number of [3 H] muscimol binding sites three-fold in rat forebrain membranes in vitro using a filtration assay, by allosterically increasing the affinities of low-affinity sites." Neurochemical research12 (1999): 1593-1602.
5. Chen, Chang-Rui, et al. "Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABAA receptor in mice." Neuropharmacology6 (2012): 1191-1199.
6. Senn, Martin W. Structures and evaluation of biologically active constituents of" Cussonia Zimmermannii" harms. Diss. University_of_Basel, 2006.
7. Martínez, M. Cecilia, et al. "Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice." Pharmacology Biochemistry and Behavior2 (2009): 291-296.
8. Fernández, Sebastián P., et al. "Synergistic interaction between hesperidin, a natural flavonoid, and diazepam." European journal of pharmacology2-3 (2005): 189-198.
9. Fernández, Sebastián, et al. "Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis." Pharmacology Biochemistry and Behavior2 (2004): 399-404.
10. Salehi, Bahare, et al. "The therapeutic potential of apigenin." International journal of molecular sciences6 (2019): 1305.
11. Kim, Jae-Wook, et al. "Enhancement of pentobarbital-induced sleep by apigenin through chloride ion channel activation." Archives of pharmacal research2 (2012): 367-373.

Gazola, Andressa C., et al. "Involvement of GABAergic pathway in the sedative activity of apigenin, the main flavonoid from Passiflora quadrangularis pericarp." Revista Brasileira de Farmacognosia 25.2 (2015): 158-163.